Overview of current research

Our research group is heavily invested in harnessing state-of-the-art technologies (both experimental and computational) in advancing the key research questions, including a fundamental understanding of 1) viral mutagenesis and evolution (and therapeutic implications), 2) molecular and cellular aspects of virus particle assembly and transmission (and therapeutic implications). We primarily study the human retroviruses – human T-cell leukemia virus (HTLV; cause of an adult T-cell leukemia) and human immunodeficiency virus (HIV; cause of AIDS). We also conduct comparative studies with a variety of other viruses.

 

Key interdisciplinary technologies we are currently employing span from quantitative imaging techniques (e.g., fluorescence microscopy at single molecule resolution, cryo-transmission electron tomography) to ultrasensitive, next-generation DNA sequencing (e.g., single-strand consensus sequencing) to large data informatics analyses (sensitive mutation detection bioinformatics analyses, 3D-reconstructions of virus particle structure). An important aspect of our research is understanding the fundamental virus-host interactions that are crucial for virus replication, virus transmission and viral pathogenesis.

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Our research group is strongly committed to the career development of predoctoral and postdoctoral students, in order to prepare them for careers in today’s workplace, which can lead in a whole variety of directions, including the directing of their own research programs. Our research group takes full advantage of the activities offered by the Institute for Molecular Virology and NIH-supported Institute for Molecular Virology Training Program.